How Does Evening Primrose Oil Work For Menopause? What's the best supplement for menopause? Black cohosh. Red clover. Dong quai. Evening primrose oil. Maca. Soy. Flax seeds. Ginseng. Does evening primrose raise estrogen levels? Evening primrose oil. There's very little recent research on the benefits of evening primrose oil for estrogen. However, one study found that of over 2,200 women that ...